Advances in treatment of achondroplasia and osteoarthritis

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Advances in research on and diagnosis and treatment of achondroplasia in China.

Achondroplasia is a rare autosomal dominant genetic disease. Research on achondroplasia in China, however, has received little emphasis. Around 80-90% of cases of neonatal achondroplasia result from mutations in fibroblast growth factor receptor 3 (FGFR3) according to polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP). Recently, genetic research on achondroplasia in Ch...

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Advances in osteoarthritis genetics

Osteoarthritis (OA), the most common form of arthritis, is a highly debilitating disease of the joints and can lead to severe pain and disability. There is no cure for OA. Current treatments often fail to alleviate its symptoms leading to an increased demand for joint replacement surgery. Previous epidemiological and genetic research has established that OA is a multifactorial disease with both...

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ژورنال

عنوان ژورنال: Human Molecular Genetics

سال: 2015

ISSN: 0964-6906,1460-2083

DOI: 10.1093/hmg/ddv419